Diamond D A, Berry S J, Jewett H J, Eggleston J C, Coffey D S
J Urol. 1982 Oct;128(4):729-34. doi: 10.1016/s0022-5347(17)53158-4.
A new technique has been developed that helped in an accurate prediction of the prognosis of 27 patients with stages B1 and B2 prostatic cancer following radical prostatectomy. This method involves computer-assisted image analysis of histological specimens of the primary lesion removed at the time of radical perineal prostatectomy. On the basis of a nuclear shape factor, known as nuclear roundness, we have been able to distinguish those tumors with a high metastatic potential from tumors that are less aggressive. This technique provides pathologists with quantitative information about the metastatic potential of a tumor, which may aid in the management of the individual patient.
一种新技术已经被开发出来，它有助于准确预测27例B1期和B2期前列腺癌患者根治性前列腺切除术后的预后。该方法涉及对经会阴根治性前列腺切除术时切除的原发性病变组织学标本进行计算机辅助图像分析。基于一种称为核圆度的核形状因子，我们已经能够区分出具有高转移潜能的肿瘤和侵袭性较小的肿瘤。这项技术为病理学家提供了关于肿瘤转移潜能的定量信息，这可能有助于对个体患者的管理。
