State Key Laboratory of Virology & Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China.
J Hazard Mater. 2011 Oct 30;194:440-4. doi: 10.1016/j.jhazmat.2011.07.113. Epub 2011 Aug 7.
Quantum dots (QDs) hold great promise in many biological applications, with the persistence of safety concerns about the environment and human health. The present work investigated the potential toxicity of CdTe QDs on the function of mitochondria isolated from rat livers by examining mitochondrial respiration, swelling, and lipid peroxidation. We observed that QDs can significantly affect the mitochondrial membrane properties, bioenergetics and induce mitochondrial permeability transition (MPT). These results will help us learn more about QDs toxicity at subcellular (mitochondrial) level.
量子点（QDs）在许多生物学应用中具有广阔的前景，但是其对环境和人类健康的安全性仍然存在担忧。本研究通过检测线粒体呼吸、肿胀和脂质过氧化，探讨了 CdTe QDs 对大鼠肝脏线粒体功能的潜在毒性。结果表明，QDs 可以显著影响线粒体膜的性质、生物能量，并诱导线粒体通透性转换（MPT）。这些结果将有助于我们在亚细胞（线粒体）水平上更多地了解 QDs 的毒性。
