Department of Medicine II, University Medical Center Freiburg, Germany.
Clin Immunol. 2011 Nov;141(2):177-86. doi: 10.1016/j.clim.2011.07.006. Epub 2011 Aug 5.
Common variable immunodeficiency (CVID) is a heterogeneous antibody deficiency syndrome with alterations in T cell regulation and function in a subgroup of patients. We assessed phenotype and function of bulk and virus-specific CD8+ T cells of a cohort of 34 HLA-A2+ CVID patients by pentamer technology and flow cytometry in relationship to their immunological and clinical phenotypes. Bulk CD8+ T cells displayed a shift toward a more antigen experienced and activated differentiation state. The advanced differentiation pattern was mainly found in a subgroup of CVID patients with lymphadenopathy and granulomatous disease. This effect existed independently of the patients' CMV status even so CMV-associated immunosenescence was more evident in CVID patients than in CMV-positive immunocompetent controls. As the phenotype and function of virus-specific CD8+ T cells were normal in CVID the induction of antiviral immunity by prophylactic immunization appears to be a logical and desirable aim for this group of patients.
普通变异性免疫缺陷症（CVID）是一种异质性抗体缺陷综合征，在亚组患者中存在 T 细胞调节和功能的改变。我们通过五聚体技术和流式细胞术评估了 34 名 HLA-A2+ CVID 患者队列的 bulk 和病毒特异性 CD8+ T 细胞的表型和功能，与他们的免疫和临床表型相关。Bulk CD8+ T 细胞表现出向更具抗原经验和激活的分化状态的转变。这种先进的分化模式主要存在于伴有淋巴结病和肉芽肿病的 CVID 患者亚组中。这种效应独立于患者的 CMV 状态存在，尽管如此，CMV 相关的免疫衰老在 CVID 患者中比在 CMV 阳性免疫功能正常对照中更为明显。由于 CVID 患者的病毒特异性 CD8+ T 细胞的表型和功能正常，预防性免疫接种诱导抗病毒免疫似乎是这群患者的一个合理且理想的目标。
