常见可变免疫缺陷病（CVID）患者的流感疫苗接种。
Influenza Vaccination in Patients with Common Variable Immunodeficiency (CVID).
机构信息
Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Medical Immunology, Augustenburger Platz 1, 13353, Berlin, Germany.
Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité University Medicine Berlin, Berlin, Germany.
出版信息
Curr Allergy Asthma Rep. 2017 Oct 5;17(11):78. doi: 10.1007/s11882-017-0749-3.
PURPOSE OF REVIEW
Vaccination against influenza in patients with primary antibody deficiency is recommended. Common variable immunodeficiency (CVID) is the most frequent and clinically relevant antibody deficiency disease and is by definition characterized by an impaired vaccination response. The purpose of this review is to present the current knowledge of humoral and cellular vaccine response to influenza in CVID patients.
RECENT FINDINGS
Studies conducted in CVID patients demonstrated an impaired humoral response upon influenza vaccination. Data on cellular immune response are in part conflicting, with two out of three studies showing responses similar to healthy controls. Available data suggest a benefit from influenza vaccination in CVID patients. Therefore, annual influenza vaccination in patients and their close household contacts is recommended.
目的综述
推荐对原发性抗体缺陷患者进行流感疫苗接种。常见可变免疫缺陷（CVID）是最常见且与临床相关的抗体缺陷疾病，其定义特征为疫苗接种反应受损。本综述的目的是介绍 CVID 患者对流感的体液和细胞疫苗反应的最新知识。
最近的发现
对 CVID 患者进行的研究表明，流感疫苗接种后会产生受损的体液反应。关于细胞免疫反应的数据部分存在冲突，其中三项研究中有两项显示出与健康对照组相似的反应。现有数据表明 CVID 患者接种流感疫苗有益。因此，建议对患者及其密切家庭接触者进行年度流感疫苗接种。
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