Center for Nanoscale Science, The Pennsylvania State University, University Park, PA 16802, USA.
Chem Commun (Camb). 2011 Oct 14;47(38):10641-3. doi: 10.1039/c1cc13002a. Epub 2011 Aug 26.
Chemical patterns prepared by self-assembly, combined with soft lithography or photolithography, are directly compared. Pattern fidelity can be controlled in both cases but patterning at the low densities necessary for small-molecule probe capture of large biomolecule targets is better accomplished using microcontact insertion printing (μCIP). Surfaces patterned by μCIP are used to capture biomolecule binding partners for the small molecules dopamine and biotin.
通过自组装制备的化学图案，与软光刻或光刻相结合，直接进行比较。在这两种情况下都可以控制图案保真度，但为了捕获大分子生物靶标上的小分子探针，最好使用微接触插入印刷（μCIP）来实现低密度的图案化。通过 μCIP 图案化的表面用于捕获小分子多巴胺和生物素的生物分子结合伴侣。
