Jandrig B
Central Institute for Cancer Research, Academy of Sciences of the GDR, Robert-Rössle-Institute, Berlin, Buch.
Arch Geschwulstforsch. 1990;60(2):141-8.
Amplification is one mechanism for activation of oncogenes and results in an excess of DNA template, which can lead to overproduction of oncogene-specific RNA and protein. Amplification of oncogenes has been observed in different tumor tissues. In certain cases amplification and overexpression of particular oncogenes have been correlated with tumor progression and clinical behavior. The best example is neuroblastoma in which the N-myc oncogene frequently is found to be amplified. Over 1,000 patients with breast cancer have been studied for amplification of the c-erbB-2 oncogene until now. The evidence from the studies that amplification of c-erbB-2 is correlated with poor prognosis is in our opinion not convincing. More and more investigations about oncogenes and disease prognosis will take place rather at the protein level than at the DNA level.
基因扩增是激活癌基因的一种机制，会导致DNA模板过量，进而可能导致癌基因特异性RNA和蛋白质的过度产生。在不同的肿瘤组织中均观察到了癌基因的扩增。在某些情况下，特定癌基因的扩增和过表达与肿瘤进展及临床行为相关。最好的例子是神经母细胞瘤，其中经常发现N - myc癌基因发生扩增。到目前为止，已经对1000多名乳腺癌患者进行了c - erbB - 2癌基因扩增的研究。我们认为，关于c - erbB - 2扩增与预后不良相关的研究证据并不令人信服。关于癌基因与疾病预后的研究将越来越多地在蛋白质水平而非DNA水平上进行。
