Morović-Vergles Jadranka, Culo Melanie Ivana, Kaliterna Dusanka Martinović
Zavod za klinicku imunologiju i reumatologiju, 10000 Zagreb.
Reumatizam. 2010;57(2):109-11.
Systemic sclerosis (SSc) is a multisystem disease whose clinical manifestations result from inflammation, vascular injury and obliteration, and cutaneous and visceral fibrosis. Scleroderma renal crisis (SRC) occurs in 5% of patients with particullary diffuse form of SSc. It is characterized by malignant hypertension and oligo/ anuric acute renal failure. SRC was once a uniformly fatal complication of SSc. The prognosis of SRC has significantly improved with the introduction of angiotensin-converting enzyme inhibitors (ACEi) as treatment. The treatment of SRC relies on tight control of blood pressure and aggressive treatment with ACEi, if needed in combination with other types of antihypertensive drugs.
系统性硬化症（SSc）是一种多系统疾病，其临床表现源于炎症、血管损伤与闭塞以及皮肤和内脏纤维化。硬皮病肾危象（SRC）发生于5%的特别是弥漫型SSc患者中。其特征为恶性高血压和少尿/无尿性急性肾衰竭。SRC曾是SSc一种一致致命的并发症。随着引入血管紧张素转换酶抑制剂（ACEi）进行治疗，SRC的预后有了显著改善。SRC的治疗依赖于严格控制血压，并在需要时联合其他类型的抗高血压药物积极使用ACEi进行治疗。
