Prus Visnja
Klinicki odjel za imunologiju i alergologiju, Josipa Huttlera 4, 31000 Osijek.
Reumatizam. 2010;57(2):115-7.
Digital ulcers occur in up to 50% of patients with limited or diffuse systemic sclerosis. The lesions are extremely painful leading to substantial functional disability, local infection susceptibility and can escalate to gangrene and amputation. Underlying vasculopathy and angiopathy cause obliteration of digital arteries and ischemic tissue changes. Management of digital ulcers includes non-pharmacological and pharmacological modalities. Early diagnosis in preclinical phase would enable preventive treatment prior to irreversible changes.
在局限性或弥漫性系统性硬化症患者中，高达50%会出现指端溃疡。这些病变极其疼痛，会导致严重的功能障碍、局部感染易感性，还可能发展为坏疽和截肢。潜在的血管病变会导致指端动脉闭塞和组织缺血性改变。指端溃疡的治疗包括非药物和药物治疗方法。临床前期的早期诊断将有助于在发生不可逆变化之前进行预防性治疗。
