Department of Rheumatology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Firenze, & Department of Geriatric Medicine, Division of Rheumatology AOUC, Firenze, Italy.
Presse Med. 2021 Apr;50(1):104064. doi: 10.1016/j.lpm.2021.104064. Epub 2021 Feb 3.
Digital ulcers (DU) are one of the most common complication of Systemic Sclerosis (SSc)-related vasculopathy and represent an important burden for the patients as well as for the society. Still today there is no agreement on the definition, classification and cathegorization of DU even if they are of pivotal importance in clinical practice, for treatment choice and prognostic outcomes, as well as for clinical trials. DU management requires a dedicated multidisciplinary team, that must remain ever vigilant for the development of infective complications and gangrene throughout their disease course, as well as patient education that is crucial to obtain the best compliance to assure the success of the treatment. Currently several drugs are available for DU treatment but in the future, more investigations will be needed to ameliorate the approach and the systemic and local therapies.
数字溃疡（DU）是系统性硬化症（SSc）相关血管病变最常见的并发症之一，对患者和社会都构成了重要负担。尽管 DU 在临床实践中对于治疗选择和预后结果以及临床试验都具有至关重要的意义，但目前对于其定义、分类和分类仍未达成共识。DU 的管理需要一个专门的多学科团队，在整个疾病过程中，必须对感染性并发症和坏疽的发展保持高度警惕，同时还需要对患者进行教育，这对于获得最佳依从性以确保治疗成功至关重要。目前有几种药物可用于 DU 的治疗，但未来还需要更多的研究来改善治疗方法和全身及局部治疗。
