Division of Infectious Diseases, Brigham & Women's Hospital, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts 02115, USA.
Antimicrob Agents Chemother. 2011 Nov;55(11):5018-21. doi: 10.1128/AAC.00536-11. Epub 2011 Aug 29.
Mortality due to mucormycosis is high. We assessed clinical characteristics and mortality among stem cell transplant and hematologic malignancy patients diagnosed with mucormycosis from 2001 to 2009. Thirty patients were diagnosed with probable or proven mucormycosis during the study. Twenty-six were diagnosed premortem, and most were treated with liposomal amphotericin B single-agent antifungal therapy initially. While the initial antifungal and surgical treatment approach remained stable throughout the study period, 6-week mortality significantly declined over time (67% in 2001 to 2003 versus 45% in 2004 to 2006 versus 20% in 2007 to 2009 [P = 0.04]), as did 12-week mortality (78% in 2001 to 2003 versus 55% in 2004 to 2006 versus 20% in 2007 to 2009 [P = 0.01]).
毛霉菌病死亡率高。我们评估了 2001 年至 2009 年间诊断为毛霉菌病的干细胞移植和血液恶性肿瘤患者的临床特征和死亡率。研究期间共诊断出 30 例可能或确诊的毛霉菌病患者。26 例在生前被诊断出来，大多数患者最初接受了两性霉素 B 脂质体单药抗真菌治疗。虽然整个研究期间初始抗真菌和手术治疗方法保持稳定，但 6 周死亡率随时间显著下降（2001 年至 2003 年为 67%，2004 年至 2006 年为 45%，2007 年至 2009 年为 20%[P=0.04]），12 周死亡率也随之下降（2001 年至 2003 年为 78%，2004 年至 2006 年为 55%，2007 年至 2009 年为 20%[P=0.01]）。
