血液系统恶性肿瘤及造血干细胞移植患者的真菌性肺炎
Fungal Pneumonia in Patients with Hematologic Malignancy and Hematopoietic Stem Cell Transplantation.
作者信息
Young Alisha Y, Leiva Juarez Miguel M, Evans Scott E
机构信息
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The University of Texas Health Sciences Center, 6431 Fannin Street, MSB 1.434, Houston, TX 77030, USA.
Division of Internal Medicine, Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1100, Houston, TX 77030, USA.
出版信息
Clin Chest Med. 2017 Sep;38(3):479-491. doi: 10.1016/j.ccm.2017.04.009. Epub 2017 May 31.
Fungal pneumonias cause unacceptable morbidity among patients with hematologic malignancies (HM) and recipients of hematopoietic stem cell transplantation (HSCT). The high incidence of fungal pneumonias in HM/HSCT populations arises from their frequently severe, complex, and persistent immune dysfunction caused by the underlying disease and its treatment. The cytopenias, treatment toxicities, and other immune derangements that make patients susceptible to fungal pneumonia frequently complicate its diagnosis and increase the intensity and duration of antifungal therapy. This article addresses the host factors that contribute to susceptibility, summarizes diagnostic recommendations, and reviews current guidelines for management of fungal pneumonia in patients with HM/HSCT.
真菌性肺炎在血液系统恶性肿瘤（HM）患者和造血干细胞移植（HSCT）受者中导致了不可接受的发病率。HM/HSCT人群中真菌性肺炎的高发病率源于其潜在疾病及其治疗导致的频繁严重、复杂和持续的免疫功能障碍。导致患者易患真菌性肺炎的血细胞减少、治疗毒性和其他免疫紊乱常常使诊断复杂化，并增加抗真菌治疗的强度和持续时间。本文探讨了导致易感性的宿主因素，总结了诊断建议，并回顾了HM/HSCT患者真菌性肺炎管理的当前指南。
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