帕金森病的情绪障碍。
Emotional dysfunction in Parkinson's disease.
机构信息
Sanders-Brown Center on Aging and Departments of Behavioral Science and Neurology, University of Kentucky College of Medicine, Lexington, USA.
出版信息
Behav Neurol. 2011;24(3):201-17. doi: 10.3233/BEN-2011-0329.
Abstract
In addition to motor symptomatology, idiopathic Parkinson's disease is characterized by emotional dysfunction. Depression affects some 30 to 40 percent of Parkinson patients and other psychiatric co-morbidities include anxiety and apathy. Neuropsychological and neuroimaging studies of emotional dysfunction in Parkinson patients suggest abnormalities involving mesolimbic and mesocortical dopaminergic pathways. There is also evidence suggesting that the interaction between serotonin and dopamine systems is important in the understanding and treatment of mood disorders in Parkinson's disease. In this review we discuss the neuropsychiatric abnormalities that accompany Parkinson's disease and describe their neuropsychological, neuropharmacologic, and neuroimaging concomitants.
摘要
除了运动症状外，特发性帕金森病的特征还包括情绪功能障碍。约 30%至 40%的帕金森病患者会出现抑郁症状，其他精神共病还包括焦虑和冷漠。对帕金森病患者情绪功能障碍的神经心理学和神经影像学研究表明，中脑边缘和中脑皮质多巴胺能通路存在异常。也有证据表明，在理解和治疗帕金森病中的情绪障碍时，5-羟色胺和多巴胺系统的相互作用很重要。在这篇综述中，我们讨论了伴随帕金森病的神经精神异常，并描述了它们的神经心理学、神经药理学和神经影像学伴随特征。
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