Facultad de Biología, Universidad de La Habana, La Habana, Cuba.
Department of Electronics and Informatics, Vrije Universiteit Brussel, Brussel, Belgium.
PLoS One. 2023 Feb 24;18(2):e0281959. doi: 10.1371/journal.pone.0281959. eCollection 2023.
Affective disorders in Parkinson's disease (PD) concern several components of emotion. However, research on subjective feeling in PD is scarce and has produced overall varying results. Therefore, in this study, we aimed to evaluate the subjective emotional experience and its relationship with autonomic symptoms and other non-motor features in PD patients. We used a battery of film excerpts to elicit Amusement, Anger, Disgust, Fear, Sadness, Tenderness, and Neutral State, in 28 PD patients and 17 healthy controls. Self-report scores of emotion category, intensity, and valence were analyzed. In the PD group, we explored the association between emotional self-reported scores and clinical scales assessing autonomic dysregulation, depression, REM sleep behavior disorder, and cognitive impairment. Patient clustering was assessed by considering relevant associations. Tenderness occurrence and intensity of Tenderness and Amusement were reduced in the PD patients. Tenderness occurrence was mainly associated with the overall cognitive status and the prevalence of gastrointestinal symptoms. In contrast, the intensity and valence reported for the experience of Amusement correlated with the prevalence of urinary symptoms. We identified five patient clusters, which differed significantly in their profile of non-motor symptoms and subjective feeling. Our findings further suggest the possible existence of a PD phenotype with more significant changes in subjective emotional experience. We concluded that the subjective experience of complex emotions is impaired in PD. Non-motor feature grouping suggests the existence of disease phenotypes profiled according to specific deficits in subjective emotional experience, with potential clinical implications for the adoption of precision medicine in PD. Further research on larger sample sizes, combining subjective and physiological measures of emotion with additional clinical features, is needed to extend our findings.
帕金森病（PD）中的情感障碍涉及情绪的几个组成部分。然而，关于 PD 中主观感觉的研究很少，且产生的结果总体上存在差异。因此，在这项研究中，我们旨在评估 PD 患者的主观情感体验及其与自主症状和其他非运动特征的关系。我们使用一系列电影片段来引发愉悦、愤怒、厌恶、恐惧、悲伤、温柔和中性状态，共 28 名 PD 患者和 17 名健康对照者。分析了情感类别的自我报告评分、强度和效价。在 PD 组中，我们探讨了情感自我报告评分与评估自主失调、抑郁、REM 睡眠行为障碍和认知障碍的临床量表之间的关联。通过考虑相关关联来评估患者聚类。PD 患者的温柔出现和温柔与愉悦的强度降低。温柔的出现主要与整体认知状态和胃肠道症状的发生率有关。相比之下，体验愉悦的强度和效价与尿症状的发生率相关。我们确定了五个患者聚类，它们在非运动症状和主观感觉方面的特征明显不同。我们的研究结果进一步表明，PD 可能存在一种表型，其主观情感体验变化更为显著。我们得出结论，复杂情感的主观体验在 PD 中受损。非运动特征分组表明存在根据主观情感体验的特定缺陷进行分类的疾病表型，这对在 PD 中采用精准医疗具有潜在的临床意义。需要对更大的样本量进行进一步研究，将情感的主观和生理测量与其他临床特征相结合，以扩展我们的研究结果。
