Walde P, Giuliani A M, Boicelli C A, Luisi P L
ETH-Zentrum, Institut für Polymere, Zürich, Switzerland.
Chem Phys Lipids. 1990 Mar;53(4):265-88. doi: 10.1016/0009-3084(90)90026-n.
Physicochemical investigations on the aggregation of phospholipids (mainly phosphatidylcholines) in organic solvents are reviewed and compared with the aggregation behaviour of phospholipids in aqueous medium. In particular we review the data showing that phosphatidylcholines (lecithins) form reverse micellar structures in certain apolar solvents. In these systems not only low molecular weight compounds but also catalytically active enzymes and entire cells can be solubilized. In addition, highly viscous phosphatidylcholine gels can be obtained in organic solvents upon solubilizing a critical amount of water. Generally, phospholipid-based reverse micelles can be regarded as thermodynamically stable models for inverted micellar lipid structures possibly occurring in biological membranes.
本文综述了磷脂（主要是磷脂酰胆碱）在有机溶剂中聚集的物理化学研究，并与磷脂在水介质中的聚集行为进行了比较。特别是，我们回顾了表明磷脂酰胆碱（卵磷脂）在某些非极性溶剂中形成反胶束结构的数据。在这些体系中，不仅低分子量化合物，而且具有催化活性的酶和完整细胞都可以被增溶。此外，在有机溶剂中溶解一定量的水后，可以得到高粘性的磷脂酰胆碱凝胶。一般来说，基于磷脂的反胶束可以被视为生物膜中可能出现的反向胶束脂质结构的热力学稳定模型。
