Yoo Seung-Schik, Kim Hyungmin, Min Byoung-Kyong, Franck Eric, Park Shinsuk
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Neuroreport. 2011 Oct 26;22(15):783-7. doi: 10.1097/WNR.0b013e32834b2957.
A pulsed application of focused ultrasound (FUS) to the regional brain tissue alters the state of tissue excitability and thus provides the means for noninvasive functional neuromodulation. We report that the application of transcranial FUS to the thalamus of anesthetized rats reduced the time to emergence of voluntary movement from intraperitoneal ketamine/xylazine anesthesia. Low-intensity FUS was applied to the thalamus of anesthetized animals. The times required for the animals to show distinct physiological/behavioral changes were measured and compared with those times required in a control session without sonication. The sonication significantly reduced the time to show pinch response and voluntary movement. The modulatory effects of FUS on anesthesia suggest potential therapeutic applications for disorders of consciousness such as minimally consciousness states.
对局部脑组织进行聚焦超声（FUS）脉冲应用可改变组织兴奋性状态，从而提供非侵入性功能性神经调节手段。我们报告称，对麻醉大鼠的丘脑进行经颅FUS应用可缩短从腹腔注射氯胺酮/赛拉嗪麻醉中苏醒至自主运动出现的时间。对麻醉动物的丘脑施加低强度FUS。测量动物出现明显生理/行为变化所需的时间，并与未进行超声处理的对照实验中的时间进行比较。超声处理显著缩短了出现捏掐反应和自主运动的时间。FUS对麻醉的调节作用表明其在意识障碍如微意识状态等方面具有潜在的治疗应用价值。
