VA RR&D Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA.
Spinal Cord. 2012 Jan;50(1):81-4. doi: 10.1038/sc.2011.92. Epub 2011 Aug 30.
Spinal cord injury (SCI) results in gastrointestinal (GI) complications, including gastroesophageal reflux disease and constipation, but much of the data is based on older technology.
GI transit times were determined in subjects with SCI using a new device called a SmartPill. Our principal goal was to assess whether this new technology can be applied in persons with SCI.
SCI and age- and gender-matched able-bodied (AB) control subjects not taking proton pump inhibitors were studied. Following an 8-h overnight fast, subjects consumed 120 g EggBeaters (60 kcal), two slices of white bread (120 kcal) and 30 g strawberry jam (74 kcal). A pH calibrated SmartPill capsule was swallowed with 8 ounces of water, after which subjects fasted for an additional 6 h prior to consuming an Ensure Plus nutrition shake (350 kcal). Subjects remained fasted for an additional 2 h, after which time they resumed their regular diets.
Twenty subjects with SCI and 10 AB control subjects were studied. Data are expressed as mean±s.d. Comparing the group with SCI to the AB control group, gastric emptying time (GET), colonic transit time (CTT) and whole gut transit time (WGTT) were prolonged (GET: 10.6±7.2 vs 3.5±1.0 h, P<0.01; CTT: 52.3±42.9 vs 14.2±7.6 h, P=0.01; WGTT: 3.3±2.5 vs 1.0±0.7 days, P<0.01). No complications or side effects were reported.
Our results indicate that the SmartPill technology is a safe, non-invasive assessment technique that provides valid diagnostic information in persons with SCI.
脊髓损伤（SCI）会导致胃肠道（GI）并发症，包括胃食管反流病和便秘，但大部分数据都是基于旧技术。
使用一种名为 SmartPill 的新设备来确定 SCI 患者的胃肠道转运时间。我们的主要目标是评估这项新技术是否可以应用于 SCI 患者。
研究了 SCI 患者和年龄、性别匹配的非残疾（AB）对照组，这些对照组没有服用质子泵抑制剂。在 8 小时的夜间禁食后，受试者食用 120 克 EggBeaters（60 卡路里）、两片白面包（120 卡路里）和 30 克草莓果酱（74 卡路里）。吞下一个 pH 校准的 SmartPill 胶囊，同时喝 8 盎司水，之后受试者在额外禁食 6 小时，然后再饮用一份 Ensure Plus 营养奶昔（350 卡路里）。受试者再禁食 2 小时，然后恢复正常饮食。
研究了 20 名 SCI 患者和 10 名 AB 对照组的受试者。数据以平均值±标准差表示。与 AB 对照组相比，SCI 组的胃排空时间（GET）、结肠传输时间（CTT）和全肠道传输时间（WGTT）延长（GET：10.6±7.2 与 3.5±1.0 h，P<0.01；CTT：52.3±42.9 与 14.2±7.6 h，P=0.01；WGTT：3.3±2.5 与 1.0±0.7 天，P<0.01）。没有报告并发症或副作用。
我们的结果表明，SmartPill 技术是一种安全、非侵入性的评估技术，可在 SCI 患者中提供有效的诊断信息。
