Mice generated from tetraploid complementation competent iPS cells show similar developmental features as those from ES cells but are prone to tumorigenesis.
作者信息
Tong Man, Lv Zhuo, Liu Lei, Zhu Hui, Zheng Qin-Yuan, Zhao Xiao-Yang, Li Wei, Wu Yi-Bo, Zhang Hai-Jiang, Wu Hua-Jun, Li Zhi-Kun, Zeng Fanyi, Wang Liu, Wang Xiu-Jie, Sha Jia-Hao, Zhou Qi
出版信息
Cell Res. 2011 Nov;21(11):1634-7. doi: 10.1038/cr.2011.143. Epub 2011 Aug 30.
Abstract
摘要
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Mice generated from tetraploid complementation competent iPS cells show similar developmental features as those from ES cells but are prone to tumorigenesis.由四倍体互补能力的诱导多能干细胞产生的小鼠表现出与胚胎干细胞产生的小鼠相似的发育特征，但易于发生肿瘤。
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本文引用的文献
1
Adult mice generated from induced pluripotent stem cells.由诱导多能干细胞产生的成年小鼠。
Nature. 2009 Sep 3;461(7260):91-4. doi: 10.1038/nature08310.
2
iPS cells produce viable mice through tetraploid complementation.诱导多能干细胞通过四倍体补偿产生存活的小鼠。
Nature. 2009 Sep 3;461(7260):86-90. doi: 10.1038/nature08267.
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iPS cells can support full-term development of tetraploid blastocyst-complemented embryos.诱导多能干细胞可支持四倍体囊胚互补胚胎的足月发育。
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