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多能干细胞：当前的认识与未来方向。

Pluripotent Stem Cells: Current Understanding and Future Directions.

作者信息

Romito Antonio, Cobellis Gilda

机构信息

Centogene, Schillingallee 68, 18057 Rostock, Germany.

Department of Biophysics, Biochemistry and General Pathology, Second University of Naples, Via L. de Crecchio 7, 80131 Napoli, Italy.

出版信息

Stem Cells Int. 2016;2016:9451492. doi: 10.1155/2016/9451492. Epub 2015 Dec 20.

DOI:10.1155/2016/9451492
PMID:26798367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4699068/
Abstract

Pluripotent stem cells have the ability to undergo self-renewal and to give rise to all cells of the tissues of the body. However, this definition has been recently complicated by the existence of distinct cellular states that display these features. Here, we provide a detailed overview of the family of pluripotent cell lines derived from early mouse and human embryos and compare them with induced pluripotent stem cells. Shared and distinct features of these cells are reported as additional hallmark of pluripotency, offering a comprehensive scenario of pluripotent stem cells.

摘要

多能干细胞具有自我更新的能力，并能分化产生身体组织的所有细胞。然而，最近由于存在表现出这些特征的不同细胞状态，这一定义变得复杂起来。在这里，我们详细概述了源自早期小鼠和人类胚胎的多能细胞系家族，并将它们与诱导多能干细胞进行比较。这些细胞的共同特征和独特特征被报告为多能性的额外标志，提供了多能干细胞的全面情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/621f/4699068/8047f9208fb0/SCI2016-9451492.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/621f/4699068/08269180ee78/SCI2016-9451492.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/621f/4699068/4dbf936543be/SCI2016-9451492.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/621f/4699068/c97d468dab5e/SCI2016-9451492.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/621f/4699068/d2a89ec2dab3/SCI2016-9451492.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/621f/4699068/8047f9208fb0/SCI2016-9451492.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/621f/4699068/08269180ee78/SCI2016-9451492.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/621f/4699068/4dbf936543be/SCI2016-9451492.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/621f/4699068/c97d468dab5e/SCI2016-9451492.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/621f/4699068/d2a89ec2dab3/SCI2016-9451492.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/621f/4699068/8047f9208fb0/SCI2016-9451492.005.jpg

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