Shearer Gene M, Boasso Adriano
F1000 Med Rep. 2011;3:12. doi: 10.3410/M3-12. Epub 2011 Jun 1.
This report revisits the accidental discovery that protection against simian immunodeficiency virus (SIV) infection in the early successful experimental AIDS vaccine studies in Rhesus macaques was due to antibodies directed against human leukocyte antigens (HLAs). The inactivated virus vaccine approach was discarded because protection was due to the host's immune reaction against the HLA acquired by SIV from the human cell lines in which it was grown, rather than against antigenic determinants of SIV itself. Subsequent studies have revealed that immune recognition of HLA on uninfected leukocytes also induces other factors that inhibit infection by both SIV and the human immunodeficiency virus. Pro and con aspects of immunization against HLA as a potential AIDS vaccine strategy are discussed.
本报告重新审视了一项意外发现，即在早期成功的恒河猴实验性艾滋病疫苗研究中，对猿猴免疫缺陷病毒（SIV）感染的保护作用归因于针对人类白细胞抗原（HLA）的抗体。灭活病毒疫苗方法被摒弃，因为这种保护作用是由于宿主针对SIV从其生长的人类细胞系中获得的HLA产生的免疫反应，而非针对SIV自身的抗原决定簇。后续研究表明，对未感染白细胞上HLA的免疫识别还会诱导其他抑制SIV和人类免疫缺陷病毒感染的因子。本文讨论了将针对HLA进行免疫作为一种潜在艾滋病疫苗策略的正反两方面情况。
