Department of Cardiothoracic Surgery, St George's Hospital, London SW17 0QT, UK.
Cardiol Res Pract. 2011;2011:164078. doi: 10.4061/2011/164078. Epub 2011 Aug 23.
Atrial fibrillation (AF) is the most common sustained arrhythmia that is associated with significant morbidity and mortality. Current available therapies remain inadequate in symptom control and secondary prevention and are often associated with significant side effects. The mechanisms underlying the pathogenesis of AF are poorly understood, although electrophysiological remodeling has been described as an important initiating step. Recently, increasing evidence implicates oxidative stress and inflammation in the pathogenesis of AF. We searched the literature for evidence to support the use of antioxidant vitamins C and E in the prevention of AF. These vitamins, through their reactive-oxygen-species- (ROS-) scavenging effect, have shown a role in AF prevention in both animal and small clinical studies. The available evidence, however, is currently insufficient to support recommendations for their use in the wider patient population. Larger-scale clinical studies are required to confirm these preliminary results. Research is also required to further the understanding of the processes involved in the pathogenesis of AF and the role of antioxidant therapies to prevent the arrhythmia.
心房颤动（AF）是最常见的持续性心律失常，与显著的发病率和死亡率相关。目前可用的治疗方法在控制症状和二级预防方面仍然不足，并且常常伴有明显的副作用。尽管已经描述了电生理重构是一个重要的起始步骤，但 AF 的发病机制仍未被充分理解。最近，越来越多的证据表明氧化应激和炎症与 AF 的发病机制有关。我们检索了文献，以寻找支持使用抗氧化维生素 C 和 E 预防 AF 的证据。这些维生素通过其清除活性氧物质（ROS）的作用，在动物和小型临床研究中均显示出在预防 AF 中的作用。然而，目前的证据尚不足以支持在更广泛的患者群体中使用它们的建议。需要更大规模的临床研究来证实这些初步结果。还需要研究来进一步了解 AF 发病机制中涉及的过程以及抗氧化治疗预防心律失常的作用。
