激素替代疗法：与健康绝经后妇女的同型半胱氨酸和氧化应激状态的关系。

Hormone replacement therapy: relation to homocysteine and prooxidant-antioxidant status in healthy postmenopausal women.

机构信息

Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Capa 34093, Istanbul, Turkey.

出版信息

Arch Gynecol Obstet. 2012 Mar;285(3):733-9. doi: 10.1007/s00404-011-2051-2. Epub 2011 Aug 30.

DOI:10.1007/s00404-011-2051-2

PMID:21877144

Abstract

OBJECTIVES

Studies have consistently shown a lower cardiovascular risk in women who received postmenopausal hormone replacement therapy (HRT).

DESIGN AND METHODS

In this study, the effects of HRT were investigated on plasma total homocysteine (tHcy) and the oxidant-antioxidant status in postmenopausal women. 35 of postmenopausal receiving (2 mg estrodiol valerate + 1 mg cyproterone acetate) HRT group, the remaining 25 received orally placebo (NHRT group).

RESULTS

There was no significant change in plasma tHcy levels between HRT and NHRT groups. Malondialdehyde (MDA) and total thiol (t-SH) correlated significantly with tHcy (0.388 and 0.478, respectively) content, and there was a significant negative correlation between E2 level and glutathione transferase (GST) activity (-0.425) in HRT group. Superoxide dismutase (SOD) and HDL-C correlated significantly with t-SH level (0.339 and 0.336, respectively) in plasma after HRT.

CONCLUSION

Our results show that HRT is beneficial in the protection against oxidative damage, and prevents atherosclerotic complications.

摘要

目的

研究表明，接受绝经后激素替代疗法（HRT）的女性心血管风险较低。

设计和方法

本研究旨在探讨 HRT 对绝经后妇女血浆总同型半胱氨酸（tHcy）和氧化还原状态的影响。35 名接受（2 毫克戊酸雌二醇+1 毫克环丙孕酮）HRT 的绝经后妇女为 HRT 组，其余 25 名接受口服安慰剂（NHRT 组）。

结果

HRT 组和 NHRT 组血浆 tHcy 水平无显著变化。丙二醛（MDA）和总巯基（t-SH）与 tHcy 含量呈显著正相关（分别为 0.388 和 0.478），HRT 组 E2 水平与谷胱甘肽转移酶（GST）活性呈显著负相关（-0.425）。超氧化物歧化酶（SOD）和 HDL-C 与 HRT 后血浆 t-SH 水平呈显著正相关（分别为 0.339 和 0.336）。