Wang Yixuan, Chen Shuohua, Yao Tao, Li DongQing, Wang YanXiu, Li YuQing, Wu ShouLing, Cai Jun
Department of Cardiology, Beijing Chao-Yang Hospital, Capital Medical University, Chaoyang District, Beijing, China.
Health Department of Kailuan Group, Tangshan, China.
PLoS One. 2014 Oct 13;9(10):e108223. doi: 10.1371/journal.pone.0108223. eCollection 2014.
Homocysteine (Hcy) is regarded as a risk factor for hypertension, but research on the causal relationship between Hcy and hypertension is limited. In the present study, we prospectively tracked the blood pressure progression of a normotensive population with different Hcy levels over a 2-year period. The incidence of hypertension with increasing Hcy quartiles produced an approximately U-shaped curve, with significance in males. Compared with the third quartile, the risk of hypertension in the first and second quartiles was increased by 1.55 (95% confidence interval [CI] 1.154-2.081) fold and 1.501 (95% CI 1.119-2.013) fold, respectively, with the increase being more significant in males. In conclusion, Hcy is related to hypertension incidence with the results approximating an U-shaped curve. Low Hcy levels might also increase the risk of hypertension.
同型半胱氨酸（Hcy）被视为高血压的一个风险因素，但关于Hcy与高血压之间因果关系的研究有限。在本研究中，我们前瞻性地追踪了不同Hcy水平的正常血压人群在两年期间的血压进展情况。随着Hcy四分位数增加，高血压发病率呈现出近似U形曲线，在男性中具有显著性。与第三个四分位数相比，第一个和第二个四分位数的高血压风险分别增加了1.55倍（95%置信区间[CI] 1.154 - 2.081）和1.501倍（95% CI 1.119 - 2.013），在男性中增加更为显著。总之，Hcy与高血压发病率相关，结果近似U形曲线。低Hcy水平也可能增加高血压风险。
