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A case of hyperpigmentation induced by hydroxychloroquine and quinacrine in a patient with systemic lupus erythematosus and review of the literature.1例系统性红斑狼疮患者由羟氯喹和阿的平引起的色素沉着病例及文献复习
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Hyperpigmentation of hard palate induced by chloroquine therapy.氯喹治疗引起的硬腭色素沉着。
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[Ocular complications of chloroquine and derivatives therapy].
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[Optical coherence tomography to evaluate peripapillary retinal nerve fiber layer in chloroquine patients].[光学相干断层扫描评估氯喹患者的视乳头周围视网膜神经纤维层]
Arq Bras Oftalmol. 2010 Jan-Feb;73(1):28-32. doi: 10.1590/s0004-27492010000100005.
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[Diagnostic methods for chloroquine diphosphate induced retinopathy in systemic lupus erythematosus].[系统性红斑狼疮中氯喹二磷酸盐诱导性视网膜病变的诊断方法]
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Pigmentation of the hard palate.
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Oral and dental adverse drug reactions.口腔和牙科药物不良反应。
Periodontol 2000. 2008;46:9-26. doi: 10.1111/j.1600-0757.2008.00226.x.
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Oral mucosal pigmentation secondary to treatment with mepacrine, with sparing of the denture bearing area.
Br J Oral Maxillofac Surg. 2004 Aug;42(4):351-3. doi: 10.1016/j.bjoms.2004.02.027.
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Adverse drug reactions in the mouth.
Clin Dermatol. 2000 Sep-Oct;18(5):525-32. doi: 10.1016/s0738-081x(00)00143-7.
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Oral mucosal hyperpigmentation secondary to antimalarial drug therapy.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000 Aug;90(2):189-94. doi: 10.1067/moe.2000.106340.

长期使用抗疟疾药物氯喹引起的腭部色素沉着。

Palate hyperpigmentation caused by prolonged use of the anti-malarial chloroquine.

作者信息

de Melo Filho Mário Rodrigues, da Silva Célsia Adriane Dias, da Rocha Dourado Maurício, de Oliveira Pires Maria Betânia, Pêgo Sabina Pena Borges, de Freitas Edmilson Martins

机构信息

Department of Dentistry, State University of Montes Claros, Montes Claros, Minas Gerais, Brazil.

出版信息

Head Neck Pathol. 2012 Mar;6(1):48-50. doi: 10.1007/s12105-011-0288-5. Epub 2011 Aug 30.

DOI:10.1007/s12105-011-0288-5
PMID:21877232
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3311937/
Abstract

The side-effects of many drugs manifest in the oral mucosa. The anti-malarial agent chloroquine diphosphate, which is also used to treat immunological, dermatological, and rheumatological disorders, usually causes pigmentary changes in the oral mucosa. This report presents a case of palate pigmentation related to the prolonged use of chloroquine diphosphate caused by the deposition of drug metabolites in the mucosa. Healthcare professionals must be aware of these drugs and their adverse effects in order to make the correct diagnosis, decide on the optimal treatment for the condition, or refer the patient to an appropriate specialist.

摘要

许多药物的副作用会在口腔黏膜中显现出来。抗疟药磷酸氯喹，也用于治疗免疫、皮肤和风湿性疾病，通常会导致口腔黏膜色素沉着变化。本报告介绍了一例因药物代谢产物在黏膜中沉积导致长期使用磷酸氯喹引起的腭部色素沉着病例。医疗保健专业人员必须了解这些药物及其不良反应，以便做出正确诊断，确定针对该病症的最佳治疗方案，或将患者转诊给合适的专科医生。