长期使用抗疟疾药物氯喹引起的腭部色素沉着。
Palate hyperpigmentation caused by prolonged use of the anti-malarial chloroquine.
作者信息
de Melo Filho Mário Rodrigues, da Silva Célsia Adriane Dias, da Rocha Dourado Maurício, de Oliveira Pires Maria Betânia, Pêgo Sabina Pena Borges, de Freitas Edmilson Martins
机构信息
Department of Dentistry, State University of Montes Claros, Montes Claros, Minas Gerais, Brazil.
出版信息
Head Neck Pathol. 2012 Mar;6(1):48-50. doi: 10.1007/s12105-011-0288-5. Epub 2011 Aug 30.
Abstract
The side-effects of many drugs manifest in the oral mucosa. The anti-malarial agent chloroquine diphosphate, which is also used to treat immunological, dermatological, and rheumatological disorders, usually causes pigmentary changes in the oral mucosa. This report presents a case of palate pigmentation related to the prolonged use of chloroquine diphosphate caused by the deposition of drug metabolites in the mucosa. Healthcare professionals must be aware of these drugs and their adverse effects in order to make the correct diagnosis, decide on the optimal treatment for the condition, or refer the patient to an appropriate specialist.
摘要
许多药物的副作用会在口腔黏膜中显现出来。抗疟药磷酸氯喹，也用于治疗免疫、皮肤和风湿性疾病，通常会导致口腔黏膜色素沉着变化。本报告介绍了一例因药物代谢产物在黏膜中沉积导致长期使用磷酸氯喹引起的腭部色素沉着病例。医疗保健专业人员必须了解这些药物及其不良反应，以便做出正确诊断，确定针对该病症的最佳治疗方案，或将患者转诊给合适的专科医生。
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