Menter Alan, Sofen Howard, Smith Stacy, Papp Kim, Kempers Steven, Hudson Charles P, Colón Luz E, Johnson Lori A, Gottschalk Ronald
Baylor Research Institute, Dallas, Texas, USA.
Cutis. 2011 Jul;88(1):46-51.
Psoriasis is a chronic condition with serious quality-of-life ramifications. Dermatologists seek alternative treatments of patients with plaque psoriasis that provide both efficacy and safety while minimizing exposure to high-potency steroids that can have adverse effects following long-term use. We report an open-label, multicenter study designed to evaluate a morning/evening (AM/PM) treatment regimen involving clobetasol propionate spray 0.05% and calcitriol ointment 3 microg/g for moderate plaque psoriasis. Participants applied clobetasol propionate spray 0.05% in the morning and calcitriol ointment 3 microg/g in the evening for up to 4 weeks. Participants were evaluated at baseline, week 2, and week 4. The results of this study indicate that a 4-week regimen of clobetasol propionate spray 0.05% treatment in the morning and calcitriol ointment 3 microg/g in the evening is efficacious and without unexpected safety issues for the management of moderate plaque psoriasis.
银屑病是一种对生活质量有严重影响的慢性疾病。皮肤科医生寻求针对斑块状银屑病患者的替代治疗方法，这些方法既要有效又要安全，同时尽量减少长期使用可能产生不良反应的高效类固醇的暴露。我们报告一项开放标签、多中心研究，旨在评估一种早晚（上午/下午）治疗方案，该方案涉及0.05%丙酸氯倍他索喷雾剂和3μg/g骨化三醇软膏用于中度斑块状银屑病。参与者在早晨使用0.05%丙酸氯倍他索喷雾剂，晚上使用3μg/g骨化三醇软膏，持续4周。在基线、第2周和第4周对参与者进行评估。这项研究的结果表明，早晨使用0.05%丙酸氯倍他索喷雾剂治疗、晚上使用3μg/g骨化三醇软膏的4周治疗方案对于中度斑块状银屑病的治疗是有效的，且没有意外的安全问题。
