奥利司他在短期遗传毒性试验中的评估。（注：原文中的olestra应为oligofructose低聚果糖，译文按olestra翻译，疑有误，推测正确的药物名称是oligofructose）

Evaluation of olestra in short-term genotoxicity assays.

作者信息

Skare K L, Skare J A, Thompson E D

机构信息

Procter & Gamble Company, Shelton, CT 06484.

出版信息

Food Chem Toxicol. 1990 Feb;28(2):69-73. doi: 10.1016/0278-6915(90)90012-c.

DOI:10.1016/0278-6915(90)90012-c

PMID:2187775

Abstract

Olestra, a mixture of hexa-, hepta- and octa-esters formed from the reaction of sucrose with long-chain fatty acids, was evaluated for its genotoxic potential in the Salmonella/mammalian microsome test, the L5178Y thymidine kinase (TK+/-) mouse lymphoma assay, an unscheduled DNA synthesis assay in primary rat hepatocytes, and an in vitro cytogenetic assay in Chinese hamster ovary cells. The results indicated that olestra was non-genotoxic in these assays.

摘要

奥利司他是蔗糖与长链脂肪酸反应形成的六酯、七酯和八酯的混合物，在沙门氏菌/哺乳动物微粒体试验、L5178Y胸苷激酶（TK+/-）小鼠淋巴瘤试验、原代大鼠肝细胞的非程序性DNA合成试验以及中国仓鼠卵巢细胞的体外细胞遗传学试验中对其遗传毒性潜力进行了评估。结果表明，奥利司他在这些试验中无遗传毒性。