Department of Molecular and Clinical Medicine, Division of Obstetrics and Gynaecology, University Hospital Linköping, Linköping, Sweden.
Gynecol Endocrinol. 2012 Jan;28(1):72-5. doi: 10.3109/09513590.2011.588744. Epub 2011 Aug 31.
Calcitonin gene-related peptide (CGRP) seems to be involved in hot flushes in women and in castrated men. Therefore, we studied whether the plasma concentrations of CGRP changed during flushes in a group of healthy aging men. Twelve men (49-71 years) with no history of current or former prostate cancer or hormonal treatment reporting ≥ 20 flushes/week were investigated. Blood samples were drawn during and between flushes for analysis of CGRP and also androgen concentrations, that is, testosterone and bioavailable testosterone were analysed. Skin temperature and skin conductance were monitored. Thirty-five flushes were reported by 10 men. The plasma concentrations of CGRP did not increase during flushes. No significant change in skin temperature or conductance was found. CGRP is probably not involved in the mechanisms of flushes in healthy aging men. Therefore, flushes in aging healthy men seem to be different from flushes in men and women deprived of sex steroids where CGRP increases during flushes.
降钙素基因相关肽（CGRP）似乎与女性和去势男性的热潮红有关。因此，我们研究了一群健康老年男性在热潮期间 CGRP 的血浆浓度是否发生变化。我们调查了 12 名（49-71 岁）没有当前或以前前列腺癌或激素治疗史、每周报告≥20 次热潮的男性。在热潮期间和之间抽取血液样本分析 CGRP 和雄激素浓度，即分析睾酮和生物可利用睾酮。监测皮肤温度和皮肤电导。10 名男性报告了 35 次热潮。热潮期间 CGRP 血浆浓度没有增加。皮肤温度或电导没有明显变化。CGRP 可能不参与健康老年男性热潮的发生机制。因此，健康老年男性的热潮似乎与失去性激素的男性和女性的热潮不同，在后者中 CGRP 在热潮期间增加。
