Lista Gianluca, Castoldi Francesca, Cavigioli Francesco, Bianchi Silvia, Fontana Paola, La Verde Azzurra
NICU, V.Buzzi Children's Hospital, ICP, Milan, Italy.
J Matern Fetal Neonatal Med. 2011 Oct;24 Suppl 1:67-8. doi: 10.3109/14767058.2011.607615. Epub 2011 Aug 31.
Hypothermia is used for its neuroprotective effect in perinatal asphyxia. Mechanical ventilation is often used as a supportive therapy for severe asphyxiated infants who can present various degrees of respiratory failure. Animal studies demonstrated a protective effect of cooling on the lungs due to reduced ventilatory requirements. Even if actual knowledge on the effects of hypothermia and rewarming on respiratory parameters during mechanical ventilation is limited, nevertheless human studies seem to demonstrate that hypothermia is safe and does not cause significant changes in the level of respiratory supports.
低温疗法因其对围产期窒息的神经保护作用而被采用。机械通气常被用作患有不同程度呼吸衰竭的重度窒息婴儿的支持性治疗方法。动物研究表明,降温可因降低通气需求而对肺部产生保护作用。尽管关于低温疗法和复温对机械通气期间呼吸参数影响的实际知识有限,但人体研究似乎表明低温疗法是安全的,且不会导致呼吸支持水平发生显著变化。