Polk H C, Lamont P M, Galland R B
Price Institute of Surgical Research, Department of Surgery, University of Louisville School of Medicine, Kentucky 40292.
Infect Immun. 1990 Jun;58(6):1807-11. doi: 10.1128/iai.58.6.1807-1811.1990.
Observations made during the study of nonspecific enhancement of antimicrobial host defenses permitted some physiologic dissection of the anatomic basis for normal protective processes. Local growth of bacteria in the hind limb in muramyl dipeptide-treated mice was suppressed modestly, but lymphatic filtration was markedly improved, especially between the ipsilateral groin and iliac lymph nodes. Spontaneous containment, when it occurred in saline-treated controls, proceeded similarly. Certain regional lymph nodes acted to restrict the dissemination of bacteria from an anatomically isolated infection, reducing the degree of bacteremia and improving survival. Containment of local bacterial infection appears more important in a favorable host response than does dispersion and is accentuated by muramyl dipeptide.
在对抗微生物宿主防御的非特异性增强研究过程中所做的观察，使得对正常保护过程的解剖学基础进行了一些生理学剖析。在经胞壁酰二肽处理的小鼠后肢中，细菌的局部生长受到适度抑制，但淋巴过滤显著改善，尤其是在同侧腹股沟和髂淋巴结之间。在生理盐水处理的对照组中出现的自发遏制情况，进展类似。某些局部淋巴结起到限制细菌从解剖学上孤立的感染灶扩散的作用，减少菌血症程度并提高生存率。在有利的宿主反应中，局部细菌感染的遏制似乎比扩散更为重要，并且胞壁酰二肽会加剧这种情况。
