Salman S M, Rogers G S
Department of Dermatology, Boston University School of Medicine, Massachusetts 02118-2394.
J Dermatol Surg Oncol. 1990 May;16(5):413-8. doi: 10.1111/j.1524-4725.1990.tb00057.x.
A small subset of patients with thin (less than 0.76 mm thick) primary cutaneous malignant melanomas develop metastases. Features that may help differentiate higher and lower risk lesions in this thickness range are reported to include the patient's age and sex, anatomic site and diameter of the primary lesion, Clark level of invasion, development of a vertical growth phase, the mitotic index, ulceration, regression, and cellular aneuploidy. In this report, we review the literature regarding the significance of these factors on the patient's prognosis.
一小部分原发性皮肤恶性黑色素瘤厚度较薄（小于0.76毫米）的患者会发生转移。据报道，在这个厚度范围内，有助于区分高风险和低风险病变的特征包括患者的年龄和性别、原发病变的解剖部位和直径、克拉克侵袭水平、垂直生长期的出现、有丝分裂指数、溃疡、消退和细胞非整倍体。在本报告中，我们回顾了有关这些因素对患者预后意义的文献。
