Department of Chemistry, University of California, Riverside, CA 92521, USA.
Anal Bioanal Chem. 2012 Jan;402(1):61-8. doi: 10.1007/s00216-011-5330-7. Epub 2011 Aug 31.
NMR is an invaluable analytical technique that provides structural and chemical information about a molecule without destroying the sample. However, NMR suffers from an inherent lack of sensitivity compared to other popular analytical techniques. This trends article focuses on strategies to increase the sensitivity of NMR using solenoidal microcoil, microstrip, and microslot probes. The role of these reduced-volume receiver coils for detection in hyphenated capillary electrophoresis (CE) and capillary isotachophoresis (cITP) NMR experiments is discussed. Future directions will likely build on work to develop probes containing multiple coils for high-throughput NMR and field-portable instruments.
NMR 是一种非常有价值的分析技术，它可以在不破坏样品的情况下提供分子的结构和化学信息。然而，与其他流行的分析技术相比，NMR 存在固有灵敏度的不足。本文综述了使用螺线管微线圈、微带和微槽探头来提高 NMR 灵敏度的策略。讨论了这些减小体积的接收线圈在毛细管电泳（CE）和毛细管等速电泳（cITP）NMR 实验中的联用检测中的作用。未来的发展方向可能是基于开发包含多个线圈的探头，以实现高通量 NMR 和现场便携式仪器的发展。
