Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, PR China.
Org Lett. 2011 Oct 7;13(19):5270-3. doi: 10.1021/ol202140y. Epub 2011 Aug 31.
A 10-step asymmetric synthesis of 9-epi-sessilifoliamide J (20), together with sessilifoliamide J (6), has been accomplished from the key chiral building block 11 via a threo-selective vinylogous Mannich reaction and a Ley oxidation-SmI(2)-mediated coupling lactonization. The absolute configuration of the natural sessilifoliamide J was established.
从关键手性砌块 11 出发，通过 threo-选择性的 vinylogous Mannich 反应和 Ley 氧化-SmI(2)-介导的偶联内酯化反应，完成了 9-epi-sessilifoliamide J（20）和 sessilifoliamide J（6）的 10 步不对称全合成。确定了天然 sessilifoliamide J 的绝对构型。
