Mazaki-Tovi Michal, Abood Sarah K, Schenck Patricia A
Department of Pathobiology and Diagnostic Investigation, Diagnostic Center for Population and Animal Health, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA.
Am J Vet Res. 2011 Sep;72(9):1259-65. doi: 10.2460/ajvr.72.9.1259.
To determine associations between serum concentrations of omega-3 polyunsaturated fatty acids and concentrations of adiponectin, leptin, and insulin in healthy cats.
56 healthy adult client-owned cats.
Body condition score (BCS) was determined, and blood samples were collected after food was withheld for 12 hours. Serum was harvested for fatty acid analysis and measurement of serum concentrations of adiponectin, leptin, insulin, glucose, triglyceride, and cholesterol.
1 cat was removed because of hyperglycemia. Significant interaction effects between BCS and serum concentrations of eicosapentaenoic acid (EPA) were detected for the analyses of associations between EPA and serum concentrations of adiponectin, insulin, and triglyceride. Cats were categorized into nonobese (BCS, 4 to 6 [n = 34 cats]) and obese (BCS, 7 to 8 [21]) groups; serum concentrations of EPA were directly associated with concentrations of adiponectin and inversely associated with concentrations of insulin and triglyceride in obese cats and were directly associated with concentrations of leptin and inversely associated with concentrations of adiponectin in nonobese cats. Additionally, serum concentrations of docosahexaenoic acid were directly associated with concentrations of adiponectin in obese cats. No significant associations between serum concentrations of docosahexaenoic acid or α-linolenic acid were detected in the analyses for all cats. Female cats had higher serum concentrations of adiponectin and lower concentrations of glucose than did male cats. Increased age was associated with a small increase in serum concentrations of leptin.
EPA may ameliorate the decrease in adiponectin and the increase in insulin and triglyceride concentrations in obese cats.
确定健康猫血清中ω-3多不饱和脂肪酸浓度与脂联素、瘦素和胰岛素浓度之间的关联。
56只健康成年客户拥有的猫。
确定身体状况评分（BCS），禁食12小时后采集血样。收集血清用于脂肪酸分析以及测定血清中脂联素、瘦素、胰岛素、葡萄糖、甘油三酯和胆固醇的浓度。
1只猫因高血糖被排除。在分析二十碳五烯酸（EPA）与脂联素、胰岛素和甘油三酯血清浓度之间的关联时，检测到BCS与EPA血清浓度之间存在显著的交互作用。将猫分为非肥胖组（BCS，4至6 [n = 34只猫]）和肥胖组（BCS，7至8 [21只]）；在肥胖猫中，EPA血清浓度与脂联素浓度直接相关，与胰岛素和甘油三酯浓度呈负相关；在非肥胖猫中，EPA血清浓度与瘦素浓度直接相关，与脂联素浓度呈负相关。此外，在肥胖猫中，二十二碳六烯酸血清浓度与脂联素浓度直接相关。在所有猫的分析中，未检测到二十二碳六烯酸或α-亚麻酸血清浓度之间存在显著关联。母猫的脂联素血清浓度高于公猫，葡萄糖浓度低于公猫。年龄增加与瘦素血清浓度略有增加有关。
EPA可能改善肥胖猫脂联素降低以及胰岛素和甘油三酯浓度升高的情况。
