Department of Veterinary Clinical and Diagnostic Sciences, Faculty of Veterinary Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, AB, Canada.
Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK, Canada.
BMC Vet Res. 2019 Sep 18;15(1):332. doi: 10.1186/s12917-019-2080-9.
Both diabetes mellitus (DM) and obesity are common in cats. The adipokines leptin, adiponectin, resistin and omentin are thought to have important roles in human obesity and glucose homeostasis; however, their functions in the pathophysiology of feline diabetes mellitus and obesity are poorly understood. We determined whether sexual dimorphism exists for circulating concentrations of these adipokines, whether they are associated with adiposity, and whether they correlate with basic indices of insulin sensitivity in cats. Healthy, client-owned male and female cats that were either ideal weight or obese were recruited into the study. Fasting blood glucose, fructosamine, cholesterol, triglycerides, insulin and plasma concentrations of adipokines were evaluated.
Obese cats had greater serum concentrations of glucose and triglycerides than ideal weight cats, but fructosamine and cholesterol concentrations did not differ between groups. Body weight and body mass index were greater in male than female cats, but circulating metabolite cocentrations were similar between sexes of both the ideal weight and obese groups. Plasma concentrations of insulin and leptin were greater in obese than ideal weight cats, with reciprocal reduction in adiponectin concentrations in obese cats; there were no sex differences in these hormones. Interestingly, plasma omentin concentrations were greater in male than female cats but with no differences between obese and ideal weight states.
Together our findings suggest that rather than gender, body weight and adiposity are more important determinants of circulating concentrations of the adipokines leptin and adiponectin. On the contrary, the adipokine omentin is not affected by body weight or adiposity but instead exhibits sexual dimorphism in cats.
糖尿病（DM）和肥胖在猫中很常见。瘦素、脂联素、抵抗素和网膜素等脂肪因子被认为在人类肥胖和葡萄糖稳态中具有重要作用；然而，它们在猫糖尿病和肥胖的病理生理学中的功能知之甚少。我们确定这些脂肪因子的循环浓度是否存在性别二态性，它们是否与肥胖有关，以及它们是否与猫的胰岛素敏感性的基本指标相关。招募了健康的、有主人的、体重理想或肥胖的雄性和雌性猫参与研究。评估了空腹血糖、果糖胺、胆固醇、甘油三酯、胰岛素和脂肪因子的血浆浓度。
肥胖猫的血清葡萄糖和甘油三酯浓度高于体重理想的猫，但果糖胺和胆固醇浓度在两组之间没有差异。雄性猫的体重和体重指数大于雌性猫，但体重理想和肥胖组的两种性别的循环代谢物浓度相似。肥胖猫的胰岛素和瘦素浓度高于体重理想的猫，而肥胖猫的脂联素浓度相应降低；这些激素在性别之间没有差异。有趣的是，雄性猫的血浆网膜素浓度高于雌性猫，但肥胖和体重理想状态之间没有差异。
我们的研究结果表明，影响循环脂肪因子瘦素和脂联素浓度的重要因素不是性别，而是体重和肥胖程度。相反，脂肪因子网膜素不受体重或肥胖程度的影响，但在猫中存在性别二态性。
