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人恶性肿瘤中的血小板衍生生长因子信号传导

Platelet-derived growth factor signaling in human malignancies.

作者信息

Liu Kun-Wei, Hu Bo, Cheng Shi-Yuan

机构信息

University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA.

出版信息

Chin J Cancer. 2011 Sep;30(9):581-4. doi: 10.5732/cjc.011.10300.

Abstract

Platelet-derived growth factors (PDGFs) and their receptors were identified and purified decades ago. PDGFs are important during normal development and in human cancers. In particular, autocrine PDGF signaling has been implicated in various types of malignancies such as gliomas and leukemia. In contrast, paracrine signaling was found in cancers that originate from epithelial cells, where it may be involved in stromal cell recruitment, metastasis, and epithelial-mesenchymal transition. This editorial briefly discusses autocrine and paracrine PDGF signaling and their roles in human cancers, and introduces a series of review articles in this issue that address the possible roles of PDGFs in various processes involved in different types of cancers.

摘要

血小板衍生生长因子(PDGFs)及其受体在数十年前就已被鉴定和纯化。PDGFs在正常发育过程以及人类癌症中都很重要。特别是,自分泌PDGF信号传导与多种类型的恶性肿瘤有关,如神经胶质瘤和白血病。相比之下,旁分泌信号传导则在源自上皮细胞的癌症中被发现,它可能参与基质细胞募集、转移以及上皮-间质转化。这篇社论简要讨论了自分泌和旁分泌PDGF信号传导及其在人类癌症中的作用,并介绍了本期的一系列综述文章,这些文章探讨了PDGFs在不同类型癌症所涉及的各种过程中的可能作用。

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