Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1105-AZ Amsterdam, The Netherlands.
J Immunol. 2011 Oct 1;187(7):3488-92. doi: 10.4049/jimmunol.1101105. Epub 2011 Aug 31.
The two outermost compartments of skin are populated by different Ag-presenting dendritic cell types. Epidermal Langerhans cells (LCs) are evolutionarily adapted to the continuous presence of harmless skin commensals by the selective lack of cell surface TLRs that sense bacteria. In this article, we analyze the ability of LCs and dermal dendritic cells (DDCs) to respond to virus infection. Live virus and intracellular TLR3-agonist dsRNA commit LCs more effectively than DDCs to stimulate naive CD8(+) T cell expansion and their differentiation into effector cells. This potent CD8(+) T cell-promoting capacity of LCs is causally related to high levels of virus-induced CD70 expression but not to IL-12 production. These data suggest a remarkable specialization of LCs in the induction of pathogen class-specific adaptive immunity. Whereas LCs ignore bacteria, they are superior to DDCs to initiate effective CD70-mediated CD8(+) T cells in response to virus stimulation.
皮肤的最外层有两种不同的 Ag 呈递树突状细胞。表皮朗格汉斯细胞 (LCs) 通过选择性缺乏感知细菌的细胞表面 TLR，适应于无害皮肤共生菌的持续存在。在本文中，我们分析了 LCs 和真皮树突状细胞 (DDCs) 对病毒感染的反应能力。活病毒和细胞内 TLR3 激动剂 dsRNA 比 DDC 更有效地促使 LCs 刺激幼稚 CD8(+)T 细胞扩增及其分化为效应细胞。LCs 这种强有力的 CD8(+)T 细胞促进能力与高水平的病毒诱导的 CD70 表达有关，但与 IL-12 产生无关。这些数据表明 LCs 在诱导病原体特异性适应性免疫方面具有显著的专业化。尽管 LCs 忽略了细菌，但它们比 DDC 更能有效地在病毒刺激时启动有效的 CD70 介导的 CD8(+)T 细胞。
