皮肤免疫。
Skin Immunity.
机构信息
Faculty of Health Science, Wroclaw Medical University, Wrocław, Poland.
Faculty of Science and Technology, Karkonosze College, Jelenia Góra, Poland.
出版信息
Arch Immunol Ther Exp (Warsz). 2018 Feb;66(1):45-54. doi: 10.1007/s00005-017-0477-3. Epub 2017 Jun 16.
Abstract
Skin is the largest organ of the body with a complex network of multitude of cell types that perform plastic and dynamic cellular communication to maintain several vital processes such as inflammation, immune response including induction of tolerance and disease prevention, wound healing, and angiogenesis. Of paramount importance are immunological functions of the skin that protect from harmful exposure coming from external and internal environments. Awareness of skin immunity can provide a better comprehension of inflammation, autoimmunity, cancer, graft-versus-host disease, vaccination, and immunotherapy approaches. This paper will update on what we currently know about immune sentinels contributing to skin immunity.
摘要
皮肤是人体最大的器官，拥有复杂的多种细胞类型网络，这些细胞通过可塑性和动态细胞通讯来维持多种重要过程，如炎症、免疫应答（包括诱导耐受和疾病预防）、伤口愈合和血管生成。皮肤的免疫功能至关重要，它可以保护人体免受来自内外环境的有害暴露。了解皮肤免疫可以更好地理解炎症、自身免疫、癌症、移植物抗宿主病、疫苗接种和免疫治疗方法。本文将更新目前关于有助于皮肤免疫的免疫哨兵的了解。
相似文献
1
Skin Immunity.皮肤免疫。
Arch Immunol Ther Exp (Warsz). 2018 Feb;66(1):45-54. doi: 10.1007/s00005-017-0477-3. Epub 2017 Jun 16.
2
Deepening our understanding of immune sentinels in the skin.加深我们对皮肤中免疫哨兵的理解。
J Clin Invest. 2007 Sep;117(9):2382-5. doi: 10.1172/JCI33349.
3
Skin, Autoimmunity and Inflammation: A Comprehensive Exploration through Scientific Research.皮肤、自身免疫与炎症：通过科学研究进行全面探索。
Int J Mol Sci. 2023 Nov 1;24(21):15857. doi: 10.3390/ijms242115857.
4
The Dynamics of the Skin's Immune System.皮肤免疫系统的动态。
Int J Mol Sci. 2019 Apr 12;20(8):1811. doi: 10.3390/ijms20081811.
5
Immunology and skin in health and disease.健康与疾病中的免疫学与皮肤
Cold Spring Harb Perspect Med. 2014 Dec 1;4(12):a015339. doi: 10.1101/cshperspect.a015339.
6
The suppressive effects of ultraviolet radiation on immunity in the skin and internal organs: implications for autoimmunity.紫外线对皮肤和内脏免疫的抑制作用：对自身免疫的影响。
J Dermatol Sci. 2012 Jun;66(3):176-82. doi: 10.1016/j.jdermsci.2011.12.009. Epub 2011 Dec 24.
7
Prospects and limitations of recombinant poxviruses for prostate cancer immunotherapy.重组痘病毒用于前列腺癌免疫治疗的前景与局限性
Curr Opin Mol Ther. 1999 Aug;1(4):471-9.
8
Skin Wound Healing: An Update on the Current Knowledge and Concepts.皮肤伤口愈合：当前知识与概念的更新
Eur Surg Res. 2017;58(1-2):81-94. doi: 10.1159/000454919. Epub 2016 Dec 15.
9
Immune cells in skin inflammation, wound healing, and skin cancer.皮肤炎症、伤口愈合及皮肤癌中的免疫细胞。
J Leukoc Biol. 2024 Apr 29;115(5):852-865. doi: 10.1093/jleuko/qiad107.
10
Leishmaniasis, contact hypersensitivity and graft-versus-host disease: understanding the role of dendritic cell subsets in balancing skin immunity and tolerance.利什曼病、接触超敏反应和移植物抗宿主病：理解树突状细胞亚群在平衡皮肤免疫和耐受中的作用。
Exp Dermatol. 2010 Aug;19(8):760-71. doi: 10.1111/j.1600-0625.2010.01116.x.
引用本文的文献
1
Evaluating the immunogenicity of a mouse partial hindlimb for composite allotransplantation.评估小鼠部分后肢复合同种异体移植的免疫原性。
Front Immunol. 2025 Jun 18;16:1595319. doi: 10.3389/fimmu.2025.1595319. eCollection 2025.
2
Autoimmune Skin Diseases and Survival Outcomes After Antineoplastic Treatment in Patients With Cancer.癌症患者接受抗肿瘤治疗后的自身免疫性皮肤病与生存结局
JAMA Dermatol. 2025 Jul 2. doi: 10.1001/jamadermatol.2025.1949.
3
Research progress on the role of fascia in skin wound healing.筋膜在皮肤伤口愈合中作用的研究进展
Burns Trauma. 2025 Apr 16;13:tkaf002. doi: 10.1093/burnst/tkaf002. eCollection 2025.
4
Tissue-resident memory T cells and their function in skin diseases.组织驻留记忆T细胞及其在皮肤病中的作用。
Chin Med J (Engl). 2025 May 20;138(10):1175-1183. doi: 10.1097/CM9.0000000000003499. Epub 2025 Mar 11.
5
Exosomes from adipose-derived stem cells accelerate wound healing by increasing the release of IL-33 from macrophages.脂肪来源干细胞分泌的外泌体通过增加巨噬细胞白细胞介素-33的释放来加速伤口愈合。
Stem Cell Res Ther. 2025 Feb 21;16(1):80. doi: 10.1186/s13287-025-04203-x.
6
Variation and assembly mechanisms of skin and cave environmental fungal communities during hibernation periods.冬眠期皮肤和洞穴环境真菌群落的变异与组装机制
Microbiol Spectr. 2025 Mar 4;13(3):e0223324. doi: 10.1128/spectrum.02233-24. Epub 2025 Jan 23.
7
Atopic dermatitis: pathogenesis and therapeutic intervention.特应性皮炎：发病机制与治疗干预
MedComm (2020). 2024 Dec 8;5(12):e70029. doi: 10.1002/mco2.70029. eCollection 2024 Dec.
8
Skin as outermost immune organ of vertebrates that elicits robust early immune responses after immunization with glycoprotein of spring viraemia of carp virus.皮肤作为脊椎动物最外层的免疫器官，在用鲤春病毒血症病毒糖蛋白免疫后能引发强烈的早期免疫反应。
PLoS Pathog. 2024 Dec 9;20(12):e1012744. doi: 10.1371/journal.ppat.1012744. eCollection 2024 Dec.
9
Incorporating immune cell surrogates into a full-thickness tissue equivalent of human skin to characterize dendritic cell activation.将免疫细胞替代物整合到全层人类皮肤组织等效物中，以表征树突状细胞的激活。
Sci Rep. 2024 Dec 4;14(1):30158. doi: 10.1038/s41598-024-81014-9.
10
Diverse Epithelial Lymphocytes in Zebrafish Revealed Using a Novel Scale Biopsy Method.利用新型鳞片活检方法揭示斑马鱼中多样的上皮淋巴细胞
J Immunol. 2024 Dec 15;213(12):1902-1914. doi: 10.4049/jimmunol.2300818.
本文引用的文献
1
Proposal of inducible skin-associated lymphoid tissue (iSALT).诱导性皮肤相关淋巴组织（iSALT）的提议。
Exp Dermatol. 2015 Aug;24(8):630-1. doi: 10.1111/exd.12716. Epub 2015 May 8.
2
Candida albicans morphology and dendritic cell subsets determine T helper cell differentiation.白色念珠菌形态和树突状细胞亚群决定辅助性T细胞分化。
Immunity. 2015 Feb 17;42(2):356-366. doi: 10.1016/j.immuni.2015.01.008. Epub 2015 Feb 10.
3
Tissue-resident memory T cells.组织驻留记忆T细胞
Immunity. 2014 Dec 18;41(6):886-97. doi: 10.1016/j.immuni.2014.12.007. Epub 2014 Dec 6.
4
Specific roles for dendritic cell subsets during initiation and progression of psoriasis.树突状细胞亚群在银屑病发生和发展过程中的特定作用。
EMBO Mol Med. 2014 Oct;6(10):1312-27. doi: 10.15252/emmm.201404114.
5
The panoply of αβT cells in the skin.皮肤中αβT细胞的全貌。
J Dermatol Sci. 2014 Oct;76(1):3-9. doi: 10.1016/j.jdermsci.2014.07.010. Epub 2014 Aug 12.
6
The origins and functions of dendritic cells and macrophages in the skin.皮肤中树突状细胞和巨噬细胞的起源和功能。
Nat Rev Immunol. 2014 Jun;14(6):417-28. doi: 10.1038/nri3683.
7
IL-23 from Langerhans cells is required for the development of imiquimod-induced psoriasis-like dermatitis by induction of IL-17A-producing γδ T cells.朗格汉斯细胞产生的白细胞介素-23通过诱导产生白细胞介素-17A的γδ T细胞，在咪喹莫特诱导的银屑病样皮炎的发展过程中是必需的。
J Invest Dermatol. 2014 Jul;134(7):1912-1921. doi: 10.1038/jid.2014.98. Epub 2014 Feb 25.
8
Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing.肥大细胞的发育及其类胰蛋白酶和糜蛋白酶丝氨酸蛋白酶在炎症和伤口愈合中的重要性。
Adv Immunol. 2014;122:211-52. doi: 10.1016/B978-0-12-800267-4.00006-7.
9
Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin.鼠皮肤中巨噬细胞和传统及单核细胞衍生树突状细胞的起源和功能特化。
Immunity. 2013 Nov 14;39(5):925-38. doi: 10.1016/j.immuni.2013.10.004. Epub 2013 Oct 31.
10
Innate lymphoid cells and allergic inflammation.先天淋巴细胞与过敏炎症。
Curr Opin Immunol. 2013 Dec;25(6):738-44. doi: 10.1016/j.coi.2013.07.013. Epub 2013 Aug 31.
Zotero 插件