酿酒酵母DNA修复基因RAD2在减数分裂中受到调控，但在有丝分裂细胞周期中不受调控。
The Saccharomyces cerevisiae DNA repair gene RAD2 is regulated in meiosis but not during the mitotic cell cycle.
作者信息
Madura K, Prakash S
机构信息
Department of Biology, University of Rochester, New York 14627.
出版信息
Mol Cell Biol. 1990 Jun;10(6):3256-7. doi: 10.1128/mcb.10.6.3256-3257.1990.
Abstract
The expression of the RAD2 gene of Saccharomyces cerevisiae is elevated upon DNA damage. Here, we show that RAD2 transcript levels also rise approximately eightfold during meiosis but remain constant during the mitotic cell cycle. The period of maximal RAD2 mRNA accumulation during meiosis is consistent with a possible role of RAD2 in a late stage of recombination, in mismatch repair of heteroduplexes, or both.
摘要
酿酒酵母的RAD2基因在DNA损伤时表达升高。在此，我们表明RAD2转录水平在减数分裂期间也会升高约八倍，但在有丝分裂细胞周期中保持恒定。减数分裂期间RAD2 mRNA积累的高峰期与RAD2在重组后期、异源双链体错配修复或两者中可能发挥的作用一致。
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