Clinique Hassiba Ben Bouali, Centre Hospitalo-Universitaire de Blida, Blida, Algérie.
Hypertens Res. 2011 Oct;34(10):1116-20. doi: 10.1038/hr.2011.111. Epub 2011 Sep 1.
The aim of this study was to evaluate whether low doses of aspirin (100 mg per day) administered to a homogeneous population of women early (8-10 weeks) during their first pregnancy improved the outcome of gestation hypertensive disorders. This study was performed at the Blida Hospital, where many early deliveries and pregnancy complications are observed. A total of 164 women were either treated (82) or used as controls (82). Treatment increased the gestation length by 12 days on average, thus triggering an approximate 150-g increase in newborn weight. This consistently improved the outcome for all patients with respect to all parameters investigated. Overall, the relative risk of developing hypertensive disorders of gestation was reduced to 0.07 (confidence interval=0.01-0.51). In our series, we did not observe deleterious consequences for the fetus (teratogenicity and fetotoxicity) or adverse outcomes for the mothers. Despite the limited number of patients analyzed, the present study is one of the largest investigating early aspirin treatment of gestational hypertensive diseases. In addition, the time of aspirin administration is among the earliest yet examined. The data tend to confirm the results obtained from other cohorts on the overall benefit of aspirin treatment for gestational disorders. In the future, molecular or ultrasonographic markers of these diseases could help to screen patients before applying the treatment.
本研究旨在评估在妊娠早期（8-10 周）对均质孕妇群体低剂量（每天 100 毫克）阿司匹林治疗是否能改善妊娠高血压疾病的结局。该研究在布利达医院进行，该院观察到许多早产和妊娠并发症。共有 164 名妇女接受治疗（82 名）或作为对照（82 名）。治疗平均使妊娠延长了 12 天，从而使新生儿体重增加了约 150 克。这一致改善了所有患者在所有调查参数方面的结局。总体而言，妊娠高血压疾病的相对风险降低至 0.07（置信区间=0.01-0.51）。在我们的系列中，我们没有观察到胎儿（致畸性和胎儿毒性）的有害后果或母亲的不良后果。尽管分析的患者数量有限，但本研究是研究妊娠高血压疾病早期阿司匹林治疗的最大研究之一。此外，阿司匹林给药时间是迄今为止研究最早的时间之一。这些数据倾向于证实其他队列研究中获得的关于阿司匹林治疗对妊娠疾病的整体益处的结果。未来，这些疾病的分子或超声标记物可以帮助在应用治疗之前筛选患者。
