Department of Internal Medicine, CES University, Fundación Valle del Lili, Cali, Colombia.
Rheumatol Int. 2012 Oct;32(10):3315-7. doi: 10.1007/s00296-011-2137-y. Epub 2011 Sep 1.
We report three patients with rheumatoid arthritis (RA) who were treated with anti-TNF-α agents and who developed drug-induced lupus (DIL). Two of them received etanercept and the remainder adalimumab. We also present the favorable response observed with the withdrawal of the anti-TNF-alpha agents and the introduction of rituximab. Through this intervention, we observed a very good control of the activity of both DIL and RA without additional adverse reactions.
我们报告了三例接受抗 TNF-α 药物治疗的类风湿关节炎（RA）患者，他们发生了药物诱导的狼疮（DIL）。其中两人接受了依那西普治疗，其余一人接受了阿达木单抗治疗。我们还介绍了停用抗 TNF-α 药物并引入利妥昔单抗后观察到的良好反应。通过这种干预，我们观察到 DIL 和 RA 的活动得到了很好的控制，没有出现其他不良反应。
