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在使用依那西普治疗期间发生肉芽肿性多血管炎

Developing of Granulomatosis with Polyangiitis during Etanercept Therapy.

作者信息

Ortiz-Sierra María Clara, Echeverri Andrés Felipe, Tobón Gabriel J, Cañas Carlos Alberto

机构信息

Department of Internal Medicine, Fundación Valle del Lili, CES University Medicine School, Medellín, Colombia.

Unit of Rheumatology, Fundación Valle del Lili, ICESI University Medicine School, Carrera 98 18-49, Cali, Colombia.

出版信息

Case Rep Rheumatol. 2014;2014:210108. doi: 10.1155/2014/210108. Epub 2014 Mar 6.

DOI:10.1155/2014/210108
PMID:24707429
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3965911/
Abstract

We describe a 67-year-old woman who developed c-ANCA positive vasculitis with involvement in eyes, skin, kidney, peripheral nerves, and upper and lower airway during treatment with etanercept therapy for rheumatoid arthritis. A diagnosis of Granulomatosis with Polyangiitis was done. Thus, anti-TNF therapy may be associated with the development of ANCA positive vasculitis.

摘要

我们描述了一名67岁女性，她在使用依那西普治疗类风湿关节炎期间发生了累及眼睛、皮肤、肾脏、周围神经以及上、下呼吸道的c-ANCA阳性血管炎。诊断为肉芽肿性多血管炎。因此，抗TNF治疗可能与ANCA阳性血管炎的发生有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e77a/3965911/a974ffb8640b/CRIRH2014-210108.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e77a/3965911/80eefe8be773/CRIRH2014-210108.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e77a/3965911/331862ce20c3/CRIRH2014-210108.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e77a/3965911/a974ffb8640b/CRIRH2014-210108.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e77a/3965911/80eefe8be773/CRIRH2014-210108.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e77a/3965911/331862ce20c3/CRIRH2014-210108.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e77a/3965911/a974ffb8640b/CRIRH2014-210108.003.jpg

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Etanercept-induced Wegener granulomatosis in a patient with rheumatoid arthritis.依那西普致类风湿关节炎患者 Wegener 肉芽肿。
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