Department of Biochemistry, Medical University of Silesia, Zabrze, Poland.
Biol Trace Elem Res. 2012 Feb;145(2):217-21. doi: 10.1007/s12011-011-9186-7. Epub 2011 Sep 1.
The effects of administration of oxidized rapeseed oil and α-lipoic acid on activities of blood antioxidant enzymes and malondialdehyde (MDA) concentration were studied in laboratory rats fed a high-fat diet. Addition of oxidized oil resulted in increased production of oxygen radicals, evidenced by elevated plasma MDA production. Such effect was counteracted by administration of α-lipoic acid. There was an increase of the activities of superoxide dismutase (total and Cu/Zn-SOD) and catalase in rats fed a high-fat diet to which 10% oxidized oil was added. Administration of α-lipoic acid resulted in a decrease of the activities of these enzymes.
研究了给高脂饮食的实验大鼠喂食氧化菜籽油和α-硫辛酸对血液抗氧化酶活性和丙二醛（MDA）浓度的影响。氧化油的添加导致氧自由基产生增加，表现为血浆 MDA 产生升高。这种作用被α-硫辛酸的给药所拮抗。给喂食添加了 10%氧化油的高脂饮食的大鼠添加α-硫辛酸会导致超氧化物歧化酶（总和 Cu/Zn-SOD）和过氧化氢酶的活性增加。α-硫辛酸的给药导致这些酶的活性降低。
