Department of Biochemistry, Silesian University of Medicine, Zabrze, Poland.
Biol Trace Elem Res. 2010 Dec;138(1-3):272-81. doi: 10.1007/s12011-010-8628-y. Epub 2010 Feb 24.
The effects of administration of oxidized rapeseed oil and α-lipoic acid on activities of hepatic antioxidant enzymes and lipid peroxidation were studied in laboratory rats. There was an increase of the activities of superoxide dismutase, glutathione peroxidase, glutathione reductase, and glucose-6-phosphate dehydrogenase in rats fed a high fat diet to which 10% oxidized oil was added. Administration of α-lipoic acid resulted in a decrease of the activities of these enzymes. Addition of oxidized oil also resulted in increased production of oxygen radicals, evidenced by elevated malondialdehyde production. Such effect was counteracted by administration of α-lipoic acid.
研究了给实验大鼠施用氧化菜籽油和α-硫辛酸对肝脏抗氧化酶和脂质过氧化活性的影响。在给喂食高脂肪饮食的大鼠添加 10%氧化油的情况下，超氧化物歧化酶、谷胱甘肽过氧化物酶、谷胱甘肽还原酶和葡萄糖-6-磷酸脱氢酶的活性增加。而给予α-硫辛酸则导致这些酶活性降低。添加氧化油还会导致氧自由基产生增加，这表现为丙二醛产量升高。α-硫辛酸的给予可对抗这种作用。
