Department of Pneumonology, Medical University of Warsaw, Banacha 1a, 02 097 Warsaw, Poland.
Inflammation. 2012 Jun;35(3):803-9. doi: 10.1007/s10753-011-9378-5.
Bronchoalveolar lavage (BAL) is a useful technique for differential diagnosis of various interstitial lung diseases (ILDs) and is usually realized by analysis of the differential cell count. This study was conducted to estimate the value of bronchoalveolar lavage fluid (BALF) total cell count (TCC) in the diagnosis of ILD. We analyzed 237 BAL samples from patients with ILD: sarcoidosis (SA), idiopathic pulmonary fibrosis (IPF), cryptogenic organizing pneumonia (COP), hypersensitivity pneumonitis (HP), chronic eosinophilic pneumonia (CEP), and smoking-related ILD (sr-ILD). The control group consisted of 30 healthy volunteers. The statistical analysis revealed significant differences in the BALF TCC between healthy controls and patients with SA, IPF, HP, COP, sr-ILD, and eosinophilic disorders (mean values 6.9 vs. 14.5, 22.5, 22.8, 20.7, 64.5, and 27.3 × 10(6), respectively). Logistic regression revealed a significant relation between the TCC and ILD diagnosis. We conclude that the TCC, as well as the value of total number of inflammatory cells, should be reported in the description of BAL.
支气管肺泡灌洗 (BAL) 是一种用于鉴别各种间质性肺疾病 (ILD) 的有用技术，通常通过分析差异细胞计数来实现。本研究旨在评估支气管肺泡灌洗液 (BALF) 总细胞计数 (TCC) 在ILD 诊断中的价值。我们分析了 237 例ILD 患者的 BAL 样本：结节病 (SA)、特发性肺纤维化 (IPF)、隐源性机化性肺炎 (COP)、过敏性肺炎 (HP)、慢性嗜酸性粒细胞性肺炎 (CEP) 和与吸烟相关的 ILD (sr-ILD)。对照组由 30 名健康志愿者组成。统计分析显示，健康对照组与 SA、IPF、HP、COP、sr-ILD 和嗜酸性粒细胞疾病患者的 BALF TCC 存在显著差异（平均值分别为 6.9×10(6)与 14.5、22.5、22.8、20.7、64.5 和 27.3×10(6)）。逻辑回归显示 TCC 与 ILD 诊断之间存在显著关系。我们得出结论，TCC 以及总炎症细胞数的值应在 BAL 描述中报告。
