Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
Mol Carcinog. 2012 Nov;51(11):861-8. doi: 10.1002/mc.20854. Epub 2011 Aug 31.
The aim of this study is to evaluate the role of adipose tissue resident stromal cells on tumor cell invasion. Our data show that a subpopulation of adipose tissue derived stromal cells expressing Nestin, NG2, α-smooth muscle actin and PDGFR-α migrate toward the cancer cells. Microarray analysis revealed the upregulation of IL-8 in the migrated cells. We demonstrated that stromal cell derived IL-8 promote the invasion and the anchorage-independent growth of cancer cells. We conclude that human breast cancer cells attract a subpopulation of stromal cells that secrete IL-8 to promote tumor cell invasion in a paracrine fashion.
本研究旨在评估脂肪组织驻留基质细胞在肿瘤细胞侵袭中的作用。我们的数据表明，一群表达巢蛋白、NG2、α-平滑肌肌动蛋白和血小板衍生生长因子受体-α的脂肪组织衍生基质细胞向癌细胞迁移。微阵列分析显示迁移细胞中白细胞介素-8 的上调。我们证明基质细胞衍生的白细胞介素-8 促进癌细胞的侵袭和非锚定依赖性生长。我们的结论是，人乳腺癌细胞吸引一群分泌白细胞介素-8 的基质细胞，以旁分泌方式促进肿瘤细胞的侵袭。
