Yin Shou-Liang, Chang Ya-Jing, Deng Su-Ping, Wang Qing-Chi, Yu Wen-Gong, Gong Qian-Hong
Key Laboratory of Marine Drugs, Ministry of Education, College of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Yao Xue Xue Bao. 2011 Jun;46(6):613-21.
In recent years, antibiotic resistance of bacteria has become a global health crisis. Especially, the new class of "superbug" was found in South Asia, which is resistant to almost known antibiotics and causes worldwide alarm. Through the underlying mechanisms of bacterial pathogenecity, the expression of many pathogen virulence factors is regulated by the process of quorum sensing. Screening efficient quorum sensing inhibitors is an especially compelling approach to the future treatment of bacterial infections and antibiotic resistance. This article focuses on bacterial quorum sensing system, quorum sensing screening model for in vitro and evaluation of animal models in vivo, recent research of quorum sensing inhibitors and so on.
近年来，细菌的抗生素耐药性已成为全球健康危机。特别是在南亚发现了新型“超级细菌”，它对几乎所有已知抗生素都具有耐药性，引起了全球恐慌。通过细菌致病性的潜在机制，许多病原菌毒力因子的表达受群体感应过程调控。筛选高效的群体感应抑制剂是未来治疗细菌感染和抗生素耐药性的一种特别有吸引力的方法。本文重点介绍细菌群体感应系统、体外群体感应筛选模型及体内动物模型评价、群体感应抑制剂的最新研究等。
