Microbial Biotechnology and Genomics, Institute of Genomics and Integrative Biology (IGIB), CSIR, Delhi University Campus, Mall Road, Delhi-110007, India.
Crit Rev Microbiol. 2011 May;37(2):121-40. doi: 10.3109/1040841X.2010.532479. Epub 2011 Jan 27.
Emergence of antibiotic and multi-drug resistant pathogenic bacteria has created the need for new drugs and drug targets. During pathogenesis bacteria release signals which regulate virulence and pathogenicity related genes. Such bacteria co-ordinate their virulent behaviour in a cell density dependent phenomenon termed as quorum sensing (QS). In contrast, microbes interfere with QS system by quenching the signals, termed quorum quenching (QQ). As a consequence of disrupted QS, pathogens become susceptible to antibiotics and drugs. In this article, the biodiversity of organisms with potential to quench QS signals and the use of QQ molecules as antibacterial drugs have been reviewed.
抗生素和多药耐药性病原菌的出现，催生了对于新药和药物靶点的需求。在发病过程中，细菌会释放信号，从而调节与毒力和致病性相关的基因。这种细菌通过一种被称为群体感应（Quorum Sensing，QS）的细胞密度依赖性现象来协调其毒力行为。相反，微生物通过淬灭信号来干扰 QS 系统，这种现象被称为群体淬灭（Quorum Quenching，QQ）。由于 QS 被破坏，病原体对抗生素和药物变得敏感。本文综述了具有淬灭 QS 信号潜力的生物多样性，以及将 QQ 分子用作抗菌药物的应用。
