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Hippocampal volume differences in Gulf War veterans with current versus lifetime posttraumatic stress disorder symptoms.有当前和终生创伤后应激障碍症状的海湾战争退伍军人的海马体积差异。
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Effects of low-level exposure to sarin and cyclosarin during the 1991 Gulf War on brain function and brain structure in US veterans.1991 年海湾战争中低水平暴露于沙林和梭曼对美国退伍军人的大脑功能和结构的影响。
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Exposure to severe wartime conditions in early life is associated with an increased risk of irritable bowel syndrome: a population-based cohort study.早年暴露于严重的战时环境与肠易激综合征风险增加有关：一项基于人群的队列研究。
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Childhood trauma and diurnal cortisol disruption in fibromyalgia syndrome.纤维肌痛综合征中的童年创伤与昼夜皮质醇紊乱
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海湾战争综合征、脑N-乙酰天门冬氨酸与创伤后应激障碍之间的关系。

The relationship between Gulf War illness, brain N-acetylaspartate, and post-traumatic stress disorder.

作者信息

Weiner Michael W, Meyerhoff Dieter J, Neylan Thomas C, Hlavin Jennifer, Ramage Erin R, McCoy Daniel, Studholme Colin, Cardenas Valerie, Marmar Charles, Truran Diana, Chu Philip W, Kornak John, Furlong Clement E, McCarthy Charles

机构信息

Center for Imaging of Neurodegenerative Diseases, VA Medical Center, 4150 Clement Street (114M), San Francisco, CA 94121, USA.

出版信息

Mil Med. 2011 Aug;176(8):896-902. doi: 10.7205/milmed-d-10-00332.

DOI:10.7205/milmed-d-10-00332
PMID:21882779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3279571/
Abstract

A previous study (Haley RW, Marshall WW, McDonald GG, Daugherty MA, Petty F, Fleckenstein JL: Brain abnormalities in Gulf War syndrome: evaluation with 1H MR spectroscopy. Radiology 2000; 215: 807-817) suggested that individuals with Gulf War Illness (GWI) had reduced quantities of the neuronal marker N-acetylaspartate (NAA) in the basal ganglia and pons. This study aimed to determine whether NAA is reduced in these regions and to investigate correlations with other possible causes of GWI, such as psychological response to stress in a large cohort of Gulf War veterans. Individuals underwent tests to determine their physical and psychological health and to identify veterans with (n=81) and without (n=97) GWI. When concentrations of NAA and ratios of NAA to creatine- and choline-containing metabolites were measured in the basal ganglia and pons, no significant differences were found between veterans with or without GWI, suggesting that GWI is not associated with reduced NAA in these regions. Veterans with GWI had significantly higher rates of post-traumatic stress disorder, supporting the idea that GWI symptoms are stress related.

摘要

先前的一项研究（哈利·R·W、马歇尔·W·W、麦克唐纳·G·G、多尔蒂·M·A、佩蒂·F、弗莱肯斯坦·J·L：海湾战争综合征中的脑异常：1H磁共振波谱评估。《放射学》2000年；215：807 - 817）表明，患有海湾战争疾病（GWI）的个体在基底神经节和脑桥中神经元标志物N - 乙酰天门冬氨酸（NAA）的含量减少。本研究旨在确定这些区域的NAA是否减少，并调查其与GWI其他可能病因的相关性，例如一大群海湾战争退伍军人对应激的心理反应。个体接受了测试，以确定他们的身心健康状况，并识别患有（n = 81）和未患有（n = 97）GWI的退伍军人。当测量基底神经节和脑桥中NAA的浓度以及NAA与含肌酸和胆碱代谢物的比率时，患有或未患有GWI的退伍军人之间未发现显著差异，这表明GWI与这些区域NAA的减少无关。患有GWI的退伍军人创伤后应激障碍的发生率显著更高，这支持了GWI症状与应激相关的观点。