Kyiv National Taras Shevchenko University, Institute of Biology, Kyiv, Ukraine.
J Enzyme Inhib Med Chem. 2012 Aug;27(4):614-7. doi: 10.3109/14756366.2011.601303. Epub 2011 Sep 2.
This article describes the photodynamic inactivation of mosquito iridescent virus (MIV) Aedes flavescens in the presence of water-soluble C(60) fullerenes. It has been observed that the photodynamic inactivation of MIV for about 1 h reduces the infectious titre of the virus in large wax-moth larvae Galleria mellonella to 4.5 lg ID(50)/mL. The influence of the C(60) concentration on its anti-viral activity was tested in the concentration range from 1 to 0.001 mg/mL. It has been found that C(60) is able to inactivate the iridovirus even in low concentrations. Consequently, the findings of this work suggest that photoexcited C(60) fullerenes can be successfully used for the inactivation of iridoviruses in biological systems.
本文描述了在水溶性 C(60)富勒烯存在的情况下，对斑纹库蚊虹彩病毒（MIV）的光动力灭活作用。实验观察到，MIV 在 1 小时左右的光动力灭活作用下，将病毒对大蜡螟幼虫 Galleria mellonella 的感染滴度降低到 4.5 lg ID(50)/mL。研究了 C(60)浓度在 1 至 0.001 mg/mL 范围内对其抗病毒活性的影响。结果发现，即使在低浓度下，C(60)也能够使虹彩病毒失活。因此，本工作的结果表明，光激发的 C(60)富勒烯可成功用于生物体系中虹彩病毒的灭活。
