贝切特病黏膜皮肤损伤中的颗粒酶 B 阳性细胞毒性 T 细胞：与结节性红斑不同的炎症反应。
Granulysin-producing cytotoxic T cells in the mucocutaneous lesions of Behçet disease: a distinct inflammatory response from erythema nodosum.
机构信息
Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan.
出版信息
Clin Exp Dermatol. 2011 Dec;36(8):903-7. doi: 10.1111/j.1365-2230.2011.04159.x. Epub 2011 Aug 25.
BACKGROUND
Cytotoxic T lymphocytes (CTLs) have been recognized as an important effector cell in Behçet disease (BD). Granulysin is a cytolytic granule protein expressed by CTLs and natural killer cells.
AIM
To evaluate the involvement of granulysin-producing T cells in the pathogenesis of BD.
METHODS
Using immunohistochemistry, lymphocyte subsets expressing granulysin were investigated in mucocutaneous lesions of BD. Serum granulysin levels were assayed by ELISA.
RESULTS
Granulysin-positive cells were seen in specimens from oral ulcers, genital ulcers and acne-like eruptions, but not erythema nodosum-like lesions. Both CD4+ and CD8+ T cells expressed granulysin. Serum granulysin levels did not correlate with disease activity in BD.
CONCLUSION
Immune reactions mediated by granulysin-positive CTLs may play an important role in the pathogenesis of acne-like eruptions, oral ulcers and genital ulcers in BD.
背景
细胞毒性 T 淋巴细胞（CTLs）已被认为是贝切特病（BD）的一种重要效应细胞。颗粒酶是 CTLs 和自然杀伤细胞表达的细胞溶酶体蛋白。
目的
评估产生颗粒酶的 T 细胞在 BD 发病机制中的作用。
方法
采用免疫组织化学方法，检测 BD 黏膜皮肤病变中表达颗粒酶的淋巴细胞亚群。采用 ELISA 法检测血清颗粒酶水平。
结果
在口腔溃疡、生殖器溃疡和痤疮样皮损标本中可见颗粒酶阳性细胞，但结节性红斑样皮损中未见。CD4+和 CD8+T 细胞均表达颗粒酶。BD 患者的血清颗粒酶水平与疾病活动度无相关性。
结论
颗粒酶阳性 CTLs 介导的免疫反应可能在 BD 的痤疮样皮损、口腔溃疡和生殖器溃疡发病机制中发挥重要作用。
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