Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Cancer Sci. 2011 Dec;102(12):2199-205. doi: 10.1111/j.1349-7006.2011.02082.x. Epub 2011 Sep 26.
In the present study, we investigated whether α-bisabolol, a sesquiterpene alcohol present in essential oils derived from a variety of plants, has antitumor effects against pancreatic cancer. α-Bisabolol induced a decrease in cell proliferation and viability in pancreatic cancer cell lines (KLM1, KP4, Panc1, MIA Paca2), but not in pancreatic epithelial cells (ACBRI515). α-Bisabolol treatment induced apoptosis and suppressed Akt activation in pancreatic cancer cell lines. Furthermore, α-bisabolol treatment induced the overexpression of early growth response-1 (EGR1), whereas EGR1 siRNA decreased the α-bisabolol-induced cell death of KLM1 cells. Tumor growth in both subcutaneous and peritoneal xenograft nude mouse models was significantly inhibited by intragastric administration of 1000 mg/kg of α-bisabolol, once a week for three weeks. The results indicate that α-bisabolol could be a novel therapeutic option for the treatment of pancreatic cancer.
在本研究中，我们研究了是否 α- 姜黄烯醇，一种存在于各种植物衍生的精油中的倍半萜醇，对胰腺癌具有抗肿瘤作用。α- 姜黄烯醇诱导胰腺癌细胞系（KLM1、KP4、Panc1、MIA Paca2）的细胞增殖和活力下降，但对胰腺上皮细胞（ACBRI515）没有作用。α- 姜黄烯醇处理诱导胰腺癌细胞系中的细胞凋亡和抑制 Akt 激活。此外，α- 姜黄烯醇处理诱导早期生长反应-1（EGR1）的过表达，而 EGR1 siRNA 降低了 KLM1 细胞中 α- 姜黄烯醇诱导的细胞死亡。每周一次经口给予 1000mg/kgα- 姜黄烯醇，连续三周，可显著抑制皮下和腹膜异种移植裸鼠模型中的肿瘤生长。结果表明，α- 姜黄烯醇可能成为治疗胰腺癌的一种新的治疗选择。
